Which condition can cause secondary osteoporosis?

Secondary osteoporosis is a condition that occurs as a result of another medical issue that affects bone density. Among the options provided, leukemia is one such condition that can lead to secondary osteoporosis. Leukemia, a type of cancer that affects blood cells, can contribute to bone density loss through various mechanisms. The disease itself may cause changes in bone marrow that disrupt normal bone remodeling. Additionally, treatments for leukemia, such as steroids or chemotherapy, can negatively impact bone health, leading to reduced bone density and increasing the risk of fractures.

Understanding the connection between systemic diseases like leukemia and bone health is crucial. In the case of leukemia, the bone marrow environment is altered, which can impair the function of osteoblasts (cells responsible for bone formation), leading to an imbalance in bone remodeling favoring resorption over formation. This ultimately results in a net loss of bone density.

The other conditions listed do not typically cause secondary osteoporosis through similar mechanisms related to direct effects on bone metabolism or marrow environment. While multiple myeloma can cause bone issues due to plasma cell infiltration in the bone, the question specifies the condition that is widely recognized for causing secondary osteoporosis, which points to leukemia.